Impaired mitochondrial function in psychiatric disorders
Identifieur interne : 000060 ( Main/Exploration ); précédent : 000059; suivant : 000061Impaired mitochondrial function in psychiatric disorders
Auteurs : Husseini Manji [États-Unis] ; Tadafumi Kato [Japon] ; Nicholas A. Di Prospero [États-Unis] ; Seth Ness [États-Unis] ; M. Flint Beal [États-Unis] ; Michael Krams [États-Unis] ; Guang Chen [États-Unis]Source :
- Nature Reviews Neuroscience [ 1471-003X ] ; 2012-05.
Abstract
Major psychiatric illnesses such as mood disorders and schizophrenia are chronic, recurrent mental illnesses that affect the lives of millions of individuals. Although these disorders have traditionally been viewed as 'neurochemical diseases', it is now clear that they are associated with impairments of synaptic plasticity and cellular resilience. Although most patients with these disorders do not have classic mitochondrial disorders, there is a growing body of evidence to suggest that impaired mitochondrial function may affect key cellular processes, thereby altering synaptic functioning and contributing to the atrophic changes that underlie the deteriorating long-term course of these illnesses. Enhancing mitochondrial function could represent an important avenue for the development of novel therapeutics and also presents an opportunity for a potentially more efficient drug-development process.
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DOI: 10.1038/nrn3229
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All Rights Reserved.</publisher><date type="published" when="2012-05">2012-05</date><biblScope unit="volume">13</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="293">293</biblScope><biblScope unit="page" to="307">307</biblScope></imprint><idno type="ISSN">1471-003X</idno></series><idno type="istex">295BBE3D33FC9BD58B12FB3F569F66D09B2442A6</idno><idno type="DOI">10.1038/nrn3229</idno><idno type="ArticleID">nrn3229</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1471-003X</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="eng">Major psychiatric illnesses such as mood disorders and schizophrenia are chronic, recurrent mental illnesses that affect the lives of millions of individuals. Although these disorders have traditionally been viewed as 'neurochemical diseases', it is now clear that they are associated with impairments of synaptic plasticity and cellular resilience. Although most patients with these disorders do not have classic mitochondrial disorders, there is a growing body of evidence to suggest that impaired mitochondrial function may affect key cellular processes, thereby altering synaptic functioning and contributing to the atrophic changes that underlie the deteriorating long-term course of these illnesses. 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